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KMID : 0369819920220040281
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Jorunal of Korean Pharmaceutical Sciences
1992 Volume.22 No. 4 p.281 ~ p.287
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Stability and dissolution Enhancement of Omeprazole by Pharmaceutical Formulation
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지웅길/Jee UK
이계원/전운종/Lee GW/Jeon UJ
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Abstract
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Omeprazole (OMZ) is very unstable in acidic solution, which selectively inhibit the release of the gastric juice in the gastric mucosa, In order to stabilize (OMZ) in oral solid dosage form, the enteric-coated microcapsules and compression-coated OMZ tablets containing lysine or arginine as stabilizer were prepared and their dissolution and stability test were performed. The haif life of OMZ microcapsules containing arginine was 194 days at 30?C and OMZ was completely released in 60 min. The half-lives of enteric coated and non-coated compression-coated OMZ tablets with lysine were 292 and 95 days at 30?C, respectively. The half-lives of enteric coated and non-coated compression-coated tablets with arginine were 1752 and 293 days at 30?C, respectively, and OMZ were released completely in 20 min in the 2nd fluid of K.P.VI. Consequently, the enteric-coated compression-coated OMZ tablets with arginine as stabilizer provided a good formulation for oral solid dosage form.
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KEYWORD
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Omeprazole, Microcapsule, Compression-coated tablet, Lysine, Arginine, Zein, HPMCP, Dissolution, Stability
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